Dear all, Our next AI seminar on *"**Upscaling Nonlinear Reactions in Tissues: Closure via Machine Learning**" *by professor Brian Wood is scheduled to be on April 20th, 1-2 PM PST. It will be followed by a 30-minute Q&A session by the graduate students. Zoom Link: https://oregonstate.zoom.us/j/93591935144?pwd=YjZaSjBYS0NmNUtjQzBEdzhPeDZ5UT... *Upscaling Nonlinear Reactions in Tissues: Closure via Machine Learning* Brian Wood Professor Chemical, Biological, and Environmental Engineering Oregon State University *Abstract:* In this work, we use a combination of formal upscaling and data-driven machine learning for explicitly closing a nonlinear transport and reaction process in a multiscale tissue. The classical effectiveness factor model is used to formulate the macroscale reaction kinetics. We parsimoniously train a multilayer perceptron network using training data generated by direct numerical simulations over thousands of microscale examples. Once trained, the network is applied in an algorithm for numerically solving the upscaled (coarse-grained) differential equation describing mass transport and reaction in two example tissues. The network is described as being explicit in the sense that the network is trained using macroscale concentrations and gradients of concentration as components of the feature space. Network training and solutions to the macroscale transport equations were computed for two different tissues. The two tissue types (brain and liver) exhibit markedly different geometry and spatial scale (cell size and sample size). The upscaled solutions for the average concentration are compared with numerical solutions derived from the microscale concentration fields by a posteriori averaging. There are two outcomes of this work of particular note: 1) we find that that the trained network exhibits good generalizability, and it is able to predict the effectiveness factor with high fidelity for realistically-structured tissues despite the significantly different scale and geometry of the two example tissue types; and 2) the approach results in an upscaled PDE with an effectiveness factor that is predicted (implicitly) via the trained neural network. This latter result emphasizes our purposeful connection between conventional averaging methods with the use of machine learning for closure; this contrasts with some machine learning methods for upscaling where the exact form of the macroscale equation remains unknown. *Speaker Bio:* Brian Wood specializes in transport phenomena at multiple scales. His research usually integrates theory, numerical simulation, and experimental data. Systems that include a biological component has been a particular focus, and recent work has involved the multiscale modeling of tissues with closures informed by machine learning. Wood has a significant and evolving interest in parsimoniously using deep neural networks to help “close” nonlinear problems in formal upscaling (e.g., multi-matieral mechanics, turbulence in fluid mechanics, etc.). The connections between thermodynamics and statistical mechanics is a personal interest; he is actively involved in research to understand how entropy, information, and complexity connect in physical systems. *Please watch this space for future AI Seminars :* * https://eecs.oregonstate.edu/ai-events <https://eecs.oregonstate.edu/ai-events>* Rajesh Mangannavar, Graduate Student Oregon State University ---- AI Seminar Important Reminders: -> For graduate students in the AI program, attendance is strongly encouraged.